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Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

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Presentation on theme: "Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension"— Presentation transcript:

1 Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension
Jörg Faber, Richard I. Gregory, Scott A. Armstrong  Cancer Cell  Volume 13, Issue 6, Pages (June 2008) DOI: /j.ccr Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Model of ABL1 and BCR-ABL1 Regulation by miR-203
miR-203 is silenced by both genetic and epigenetic mechanisms in lymphomas expressing high levels of ABL1 and in BCR-ABL1-rearranged leukemias. The loss of MiR-203 leads to elevated expression of its direct targets ABL1 and BCR-ABL1, which enhances cell proliferation. Cancer Cell  , DOI: ( /j.ccr ) Copyright © 2008 Elsevier Inc. Terms and Conditions


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