1. Stupp Trial: Improved survival with TMZ Chemotherapy
100 90 80
RT + TMZ 70 RT 60
Probability of OS (%) 50 40 30 20 10 6 12 18 24 30 36 42
Months
No. at Risk RT
RT+TMZ
HR 0.63 (95% Cl, 0.52 to 0.75; p<0.001)
Adapted from Scrive et al. ASTRO 2007

2. Long-term Survival Radiation therapy Combination P value 2 years 10.9%
27.2%
P<0.0001
3 years
4.4%
16.0%
4 years
3.0%
12.1%
Adapted from Mirimanoff et al. ASTRO 2007.

3. MGMT Gene Status: Survival at Four Years
Radiation therapy
Combination therapy
P value
Methylated MGMT promoter
5.2%
22.1%
P<0.04
Non-methylated MGMT promoter 0%
11.1%
P=0.035
Adapted from Mirimanoff et al. ASTRO 2007.