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RAS and ROS—A Story of Pseudomonas Survival

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Presentation on theme: "RAS and ROS—A Story of Pseudomonas Survival"— Presentation transcript:

1 RAS and ROS—A Story of Pseudomonas Survival
Stacey L. Kolar, George Y. Liu  Cell Host & Microbe  Volume 21, Issue 5, Pages (May 2017) DOI: /j.chom Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Pseudomonas aeruginosa ExoS Targets Ras to Inhibit NADPH-Oxidase Complex Assembly P. aeruginosa uses a type three secretion syringe to inject effector proteins, including ExoS, to manipulate host cells. ExoS ADP-ribosylates Ras, which physically blocks its interaction with PI3K. This interferes with the activation of NADPH oxidase by Akt and PKC, which inhibits assembly and ultimately ROS production. Cell Host & Microbe  , DOI: ( /j.chom ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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