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Rab3 GTPase Lands Bruchpilot

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Presentation on theme: "Rab3 GTPase Lands Bruchpilot"— Presentation transcript:

1 Rab3 GTPase Lands Bruchpilot
Nikolaos Giagtzoglou, Timothy Mahoney, Chi-Kuang Yao, Hugo J. Bellen  Neuron  Volume 64, Issue 5, Pages (December 2009) DOI: /j.neuron Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Rab3 GTPase Contributes in Active Zone Assembly
(A) The active zone of the synapses is the specialized region of the presynaptic terminal where synaptic vesicles cluster. Brp is a structural component of the active zone. Additional Brp molecules coalesce to form a T bar, near which synaptic vesicles cluster and cacophony Ca2+ channels localize. Rab3 positively regulates the addition of Brp molecules to nascent synapses, perhaps functioning through RIM. Upon activation of the channels by an action potential, Ca2+ enters the terminal, causing synaptic vesicles to fuse and release neurotransmitter molecules into the synaptic cleft. (B) Transmission electron microscopy micrograph reveals the characteristic T bar-shaped structure of the CAZ at the Drosophila larval NMJ (when using standard fixation protocols). Note the clustering of the synaptic vesicles around the T bar and the electron-dense region of the plasma membrane. Neuron  , DOI: ( /j.neuron ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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