1. Tissue Repair
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2. Methods of Tissue Repair
Two methods:
Regeneration (Replacement)
destroyed tissue is replaced by the same kind of cells;
Mitosis: cells divide to make new ones
Fibrosis (Repair)
dense (fibrous) connective tissue (scar tissue) replaces the original tissue
Method is determined by:
Type of tissue damaged
Severity of the injury
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3. Events in Tissue Repair
Inflammation
Capillaries become very permeable
Clotting proteins migrate into the area
A clot (visible fibers from blood) walls off the injured area
Granulation tissue forms
Growth of new capillaries
Rebuild of collagen fibers to form a bridge
Surface epithelium grows underneath
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4. Tissue Repair = SCAR TISSUE
The severity of the wound determines the extent of scarring
Scar tissue:
Many collagen fibers
Lacking blood supply
Very strong
No flexibility or elasticity
Loss of normal function of original tissue
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5. Tissues that: regenerate easily/well regenerate poorly
Epithelial tissue (skin and mucous membranes)
Fibrous connective tissues and bone
regenerate poorly
Skeletal muscle
Dense connective tissues: tendons, ligaments
Are replaced largely with scar tissue
Cardiac muscle
Nervous tissue within the brain and spinal cord
© 2015 Pearson Education, Inc.