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Volume 148, Issue 1, Pages e2 (January 2015)

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1 Volume 148, Issue 1, Pages 77-87.e2 (January 2015)
Association Between Molecular Subtypes of Colorectal Cancer and Patient Survival  Amanda I. Phipps, Paul J. Limburg, John A. Baron, Andrea N. Burnett-Hartman, Daniel J. Weisenberger, Peter W. Laird, Frank A. Sinicrope, Christophe Rosty, Daniel D. Buchanan, John D. Potter, Polly A. Newcomb  Gastroenterology  Volume 148, Issue 1, Pages e2 (January 2015) DOI: /j.gastro Copyright © 2015 AGA Institute Terms and Conditions

2 Figure 1 Kaplan-Meier survival curves comparing disease-specific survival in colorectal cancer patients by tumor subtype: type 1 (dashed black), type 2 (dotted black), type 3 (solid gray), type 4 (solid black), type 5 (dashed gray), some other tumor marker combination (dotted gray). Subtypes are defined as follows: type 1 = MSI-high, BRAF-mutated, KRAS-mutation–negative, CIMP+; type 2 = MSS/MSI-low, BRAF-mutated, KRAS-mutation–negative, CIMP+; type 3 = MSS/MSI-low, BRAF-mutation–negative, KRAS-mutated, non-CIMP; type 4 = MSS/MSI-low, BRAF-mutation–negative, KRAS-mutation–negative, non-CIMP; type 5 = MSI-high, BRAF-mutation–negative, KRAS-mutation–negative, non-CIMP. Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

3 Figure 2 Kaplan-Meier survival curves comparing overall survival in colorectal cancer patients by tumor subtype: type 1 (dashed black), type 2 (dotted black), type 3 (solid gray), type 4 (solid black), type 5 (dashed gray), some other tumor marker combination (dotted gray). Subtypes are defined as follows: type 1 = MSI-high, BRAF-mutated, KRAS-mutation–negative, CIMP+; type 2 = MSS/MSI-low, BRAF-mutated, KRAS-mutation–negative, CIMP+; type 3 = MSS/MSI-low, BRAF-mutation–negative, KRAS-mutated, non-CIMP; type 4 = MSS/MSI-low, BRAF-mutation–negative, KRAS-mutation–negative, non-CIMP; type 5 = MSI-high, BRAF-mutation–negative, KRAS-mutation–negative, non-CIMP. Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

4 Supplementary Figure 1 Distribution of tumor marker combinations and subtype classifications. Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions


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