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WELCOME
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A SEMINAR ON
“Laxatives”
Presented by
MAHARUDRA S. RAKH
M. PHARM ., M.B.A
E- mail:
PHARMACOGNOSY
First year

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Laxatives
Latin: Laxare:- means to -loosen
Laxatives are the drugs which loose the bowels (intestine)
Depending upon the intensities of drug effects they are categorized as follows-
Laxatives: suggest the elimination of soft formed stools (mild purgatives) ex. Senna, isapgol, liquid paraffin
Purgatives: suggest more fluid evaluation ex. Castor oil, aloe, rhubarb, cascara
Drastics: act intensely by irritating the mucous membrane of intestine ex. Jalap, podophyllum, colocynth
Hydrogogues: produce fluid motions ex. croton oil, colocynth
The mechanism of action of laxatives may be either bulk forming, irritant or emolllient depending upon the chemical nature of active constituent.
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Identification
mixes with half its volume of light petroleum ether ( °)
soluble in alcohol and insoluble in mineral oil
Uses
cathartic, lubrication, soap and textile industry,
in preparation of paints, enamel, varnishes, grease, polishes, printing ink, spirit
in preparation of ointments, creams and polishes
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ISPAGHULA
Synonyms: isapgol, isabgol
Biological source:
It consists of dried seeds of the plant known as Plantogo ovata Forskal belonging to family Plantaginaceae.
Geographical distribution:
In india mainly in gujarat, punjab, south rajasthan.
Morphological characteristics:
Colour: pinkish-grey or brown
Odour: none
Taste: mucilaginous, bland
Shape: ovate like
Size: 10-35mm length and 1 to 1.75mm in width
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Chemical constituents:
Contain mucilage, pentosan, sldobionic acid, rhamnose, fixed oil, and proteins
Uses:
Demulcent, laxative, emollinent, dysentery, in prep tablets and as stabilizer in icecream industry, in rheumatic pains
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