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Rethinking bioactivity of FLT3 inhibitors

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Presentation on theme: "Rethinking bioactivity of FLT3 inhibitors"— Presentation transcript:

1 Rethinking bioactivity of FLT3 inhibitors
by Thomas Fischer Blood Volume 117(12): March 24, 2011 ©2011 by American Society of Hematology

2 FL indicates FLT3 ligand; E, extracellular domain of FLT3; TM, transmembrane domain; JM, juxtamembrane domain; TKD1, tyrosine kinase domain 1; TKD2, tyrosine kinase domain 2; TKI, tyrosine kinase inhibitor; AGP, alpha-1 acid glycoprotein; and FLT3-ITD, FLT3... FL indicates FLT3 ligand; E, extracellular domain of FLT3; TM, transmembrane domain; JM, juxtamembrane domain; TKD1, tyrosine kinase domain 1; TKD2, tyrosine kinase domain 2; TKI, tyrosine kinase inhibitor; AGP, alpha-1 acid glycoprotein; and FLT3-ITD, FLT3 receptor with internal tandem duplication mutation. Thomas Fischer Blood 2011;117: ©2011 by American Society of Hematology

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