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Shedding Light on HDL: Myths and Controversies

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Presentation on theme: "Shedding Light on HDL: Myths and Controversies"— Presentation transcript:

1 Shedding Light on HDL: Myths and Controversies

2 Panelists

3 The HDL Hypothesis

4 Residual Clinical Risk in Statin Trials

5 TNT: On-Treatment HDL-C Predicts CV Event 5-Year Risk When LDL-C Is < 70 mg/dL

6 Infusing HDL Slows Development and Promotes Regression of Atherosclerosis

7

8 AIM-HIGH: Study Design

9 AIM-HIGH: HDL-C After 36 Months of Follow-up

10 Current Pharmacologic Approaches to Raising HDL-C

11 SATURN: Change in LDL-C and HDL-C From Baseline

12

13 Evidence From Prior Placebo-Controlled Trials Supporting Niacin Benefit

14 CETP Inhibitors: Past and Present

15 CETP Deficiency

16 CETP Deficiency: Genotype and CAD Risk

17

18 ILLUMINATE: Protocol-Specified Outcomes

19 DEFINE: BP Results at 18 Months

20

21 Evacetrapib: BP Results

22 Comparison of CETP Inhibitors

23 DEFINE: Effect of Anacetrapib on Lp(a)

24 Ongoing CETP Outcomes Trials

25 Program Summary

26

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