1. You Can Breathe Easy: IFNλ Handles Flu without Triggering a Damaging Inflammatory Response 
Bridget A. Robinson, Timothy J. Nice 
Immunity 
Volume 46, Issue 5, Pages (May 2017)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
IFNλ Clears Sub-lethal Influenza Virus Infection in the Absence of a Pro-inflammatory Response
A sub-lethal dose of influenza virus results in early IFNλ induction in infected epithelial cells and dendritic cells (DCs), as well as subsequent signaling to induce an anti-viral state that clears the virus with limited inflammation. In Ifnlr1−/− mice, low-dose influenza replicates to higher titer and results in earlier upregulation of IFNα/β, which subsequently induces expression of pro-inflammatory cytokines and chemokines by neutrophils. Increased inflammatory cytokines result in increased immune cell infiltration and decreased lung function.
Immunity  , DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions