1. Pyroptosis: Caspase-11 Unlocks the Gates of Death
Aude de Gassart, Fabio Martinon 
Immunity 
Volume 43, Issue 5, Pages (November 2015)
DOI: /j.immuni
Copyright © 2015 Elsevier Inc. Terms and Conditions

2. Figure 1 Model of Caspase-11 Mediated P2X7 Pyroptosis
The caspase-11 inflammasome is activated by the delivery of LPS molecules in the cytoplasm. Oligomerization of caspase-11 triggers its proteolytic activity that cleaves off the C-terminal portion of the membrane channel pannexin-1. Upon cleavage, the pannexin-1 channels open and contribute to ATP release and potassium efflux. Concurrently, cytoplasmic LPS primes, by an unknown mechanism, the ATP-gated P2X7 receptors. These receptors become sensitive to the nanomolar concentrations of ATP released by pannexin-1. They form pores at the membrane that eventually cause membrane rupture and the release of cellular content, including the DAMPs driving inflammation.
Immunity  , DOI: ( /j.immuni )
Copyright © 2015 Elsevier Inc. Terms and Conditions