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Sky W. Brubaker, Denise M. Monack  Immunity 

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Presentation on theme: "Sky W. Brubaker, Denise M. Monack  Immunity "— Presentation transcript:

1 Cell-Intrinsic Defense at the Epithelial Border Wall: Salmonella Pays the Price 
Sky W. Brubaker, Denise M. Monack  Immunity  Volume 46, Issue 4, Pages (April 2017) DOI: /j.immuni Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 NAIP-NLRC4 Inflammasome Activation within the Cytosol of Intestinal Epithelial Cells During Salmonella infection, the NAIP-NLRC4 inflammasome can activate either Caspase-1 or Caspase-8, triggering an IEC-intrinsic response that limits bacterial burden. Caspase-1 activation results in a coordinated rapid cell death (pyroptosis) and cell expulsion, whereas Caspase-8 activation results in cell expulsion without coordinated cell death. Dotted arrows indicate mechanisms that remain to be characterized. Immunity  , DOI: ( /j.immuni ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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