1. Volume 145, Issue 3, Pages 554-565 (September 2013)
Identification of Molecular Subtypes of Gastric Cancer With Different Responses to PI3- Kinase Inhibitors and 5-Fluorouracil 
Zhengdeng Lei, Iain Beehuat Tan, Kakoli Das, Niantao Deng, Hermioni Zouridis, Sharon Pattison, Clarinda Chua, Zhu Feng, Yeoh Khay Guan, Chia Huey Ooi, Tatiana Ivanova, Shenli Zhang, Minghui Lee, Jeanie Wu, Anna Ngo, Sravanthy Manesh, Elisabeth Tan, Bin Tean Teh, Jimmy Bok Yan So, Liang Kee Goh, Alex Boussioutas, Tony Kiat Hon Lim, Horst Flotow, Patrick Tan, Steven G. Rozen 
Gastroenterology 
Volume 145, Issue 3, Pages (September 2013)
DOI: /j.gastro
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2. Figure 1
Study design. DAVID, Database for Annotation, Visualization, and Integrated Discovery; G-DIF, genomic diffuse; G-INT, genomic intestinal.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2013 AGA Institute Terms and Conditions

3. Figure 2
Three subtypes of gastric cancer. CHC_IFS strongly supported 3 subtypes of gastric adenocarcinoma as indicated by the consensus matrices for (A) all Singapore tumors, and for (B) a selected set of highly representative tumors, SG201 (Supplementary Materials and Methods). Supplementary Figure 3 shows evidence that there are 3 subtypes.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2013 AGA Institute Terms and Conditions

4. Figure 3
Systematic differences among the 3 subtypes. (A) Gene signatures and KEGG and GO annotations for the 3 subtypes. (B) Pathway activity. Each column represents 1 tumor sample. Each row represents pathway activities computed by BFRM from the pathway seed gene set indicated on the right. Arrow indicates row for an mTOR pathway. Supplementary File PathwayAcivity.xlsx provides the numeric pathway activities and the sources of the seed gene sets. (C) The number of cytobands with CNA by subtype (P values by Kruskal–Wallis test). (D) The number of tumors in each subtype in the low or high CNA group (Bonferroni-adjusted P values by hypergeometric tests). (E) The numbers of aberrantly methylated CpGs that are hypermethylated and hypomethylated for each subtype (Bonferroni-adjusted P values by hypergeometric tests).
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2013 AGA Institute Terms and Conditions

5. Figure 4
Cancer-specific survival of patients with and without 5-FU treatment. Kaplan–Meier plots for patients treated with surgery alone vs surgery plus 5-FU for each of the 3 subtypes. K-M log-rank p, P value of the log-rank test. Cox p, P value from Cox proportional hazards models that include TNM stage as a covariate (Table 1). Only cancer-related deaths were treated as events.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2013 AGA Institute Terms and Conditions