1. Nicholas J. Silvestri, M.D.
Brains & Gains 2013
Nicholas J. Silvestri, M.D.

2. Neuromuscular Disorders
Nerve
Muscle
Nerve-Muscle Junction

3. Human Nerve

4. Nerve

5. Neuropathy = Nerve Damage
2 major types of neuropathy
Axonal: “wire damage”
Demyelinating: “insulation damage”
Another way to group neuropathy
Acquired
Inherited

6. Acquired Neuropathy Guillain-Barré syndrome Rapid onset
Post-infection or vaccination
Demyelinating
Weakness, numbness, pain, breathing difficulty

7. International, multi-center collaboration
Observational study
Looking at demographic factors, preceding infections, genetic factors, antibodies and other mediators, and clinical and electrophysiological characteristics of patients presenting within 2 weeks of onset

8. Inherited Neuropathy
Charcot-Marie-Tooth disease

9. Charcot Marie Tooth Disease
Very basic science
Hunter James Kelly Research Institute
Looking at problems with genes and their proteins that lead to abnormal myelin
Mouse models

11. Vitamin D Diabetic neuropathy Muscle disease caused by “statins”
Lou Gehrig’s disease

12. Myasthenia Gravis

13. Myasthenia Gravis

15. Thank You