1. 100,000 Genomes Haematolgical Malignancies Update
Week ending 27th July 2018

2. Haem Onc Recruitment

3. Haem Onc Recruitment Forecast

4. Haem Onc UKB Submitted UKB SUBMISSION 27/07/2018 Row Labels Haemonc
Haemonc_AML
haemonc_
cll
Haemonc_
Lymphoma
Haemonc_multiple myeloma
MDS
Grand Total
Greater Manchester 22 2 24
North East and Cumbria 12
North Thames 84
Oxford 74 14 6 4
100
South London 30
Wessex
West London 36
West Midlands 34
West of England
326
354

5. Updates Haem Onc Webex held on 6th July
Haem Onc WGS reporting guidance
First Myeloma results
Update on progress with validation cohorts
Monthly Haem Onc Leads Calls (next is on Wednesday 29th August)
Measures to facilitate recruitment of Haematological Participants
Programme extension (now all Cancer)
Reduced DNA requirements for germline DNA in Haematological Malignancies*
Germline validation pilots
Uncultured skin biopsy
Enriched T- Cells (for myeloid malignancies)
·       
*Whenever possible at least 4ug of DNA should be sent for germline as this will allow for any repeat testing that may be necessary. Where it is not possible to send 4ug of DNA it is permissible to submit less (absolute minimum of 1.3ug, with a minimum concentration of 20ng/ul and minimum volume of 66ul). Service desk must be notified when sending <4ug.