1. TOPIC: What would you do if… MT 16, Human Genetics Disorders Just
Tues
TOPIC:
MY GOAL:
Just
Somethin
to think
about…
What
would
you do
if…
I will… differentiate between a karyotype & a pedigree  finish my ‘baby’
you knew you were going to have a
child with a genetic disorder…. The
disorder may be physical, mental or
both…..What would you do???

2. POLYGENIC INHERITANCE

3. Poly = many, Genic = genes
When a single trait is controlled by 2 or more alleles
Most human traits
Hair color
skin color
eye color
height

4. KARYOTYPE

5. KARYOTYPE 46 xsomes: 2 are sex xsomes: 1pr: XX or XY 44 are autosomes
egg - X or X
sperm - X or Y X X X Y
Sperm determines sex of the offspring

6. REVIEW: Karyotype - Male or female? - Normal or abnormal?

7. REVIEW: - What indicates this is a male. - Normal or abnormal
REVIEW: - What indicates this is a male? - Normal or abnormal? - How many PAIRS of xsomes do we have?

8. PEDIGREE

9. PEDIGREE; Which symbol represents Males? Females?
Since it is unethical to use humans as test subjects, and it would take too long to get results anyway, one of the best ways to study human patterns of inheritance is to go back in time
Which symbol represents Males? Females?
Which are the oldest? Youngest?
How many generations?
What does the shaded symbol mean?
How many children did II-7 & 8 have?
How many children did I-1 & 2 have?
If III-1 produced a child, what is the chance she will produce a child who is affected?
Squares
Circles
Left
Right
III
Genetically Affected
Four
Five
50% if husband hetero – 0% if he is homozygous 9

10. Finish your baby!

11. Be the change you wish to see in the world
Study…? A little bit…?
HOMEWORK
Be the change you wish to see in the world 11 11