1. Introduction to Biosensors
Xingwei (Vivian) Wang, Ph.D.
Professor
Department of Electrical and Computer Engineering
University of Massachusetts Lowell
Phone: (978)

2. Important Links http://faculty.uml.edu/xwang/
Contact
Phone:
Office:  BL 403   

3. What is a Biosensor
A device that uses biological components e.g. enzymes to indicate the amount of a biomaterial
Trace biomaterial?
– Unnecessary (Eg. Metal ion, etc.)
Quantitative results?
– Unnecessary (Eg., Pregnancy test)

4. Components Bio Recognition Element Transducer Signal Output
Enzymes; Antibodies; Receptors; Whole cells...
Electrochemical
Optical
Transducer
Signal Output
Requires:
Simple read out and data interpretation;
Easy to use;
Quick response.
Requires: Sample Immobilization

5. Performance Factors Sensitivity: Concentration; weight
Specificity/Selectivity: discriminate between substrates
Speed: Bench->Chip->Real Time
Accuracy: False signal
Cost
Easy to use
Life time

6. Videos
(Nanosensor chips for early cancer detection)

7. Suggested Project Topics
1.      Photoacoustic/ultrasound sensors for biomedical applications
2.      Fast response biosensors
3.      In-vivo blood pressure sensor (St. Jude Medical)
4.       Intravascular ultrasound imaging (IVUS) (Volcano)
5.       Biosensor integration/miniaturization
6. Optical coherence tomography (OCT)
Nano-Biosensor
Bio-inspired sensors
Other topics related to your background