1. Retrieve Protocol for Execution (RPE)
Value Proposition: RPE will greatly simplify a healthcare site’s participation in clinical research by integrating workflow from the research protocol into the work processes of patient care.

2. Retrieve Protocol for Execution (RPE)
Abstract: The Retrieve Protocol for Execution Profile (RPE) provides an automated mechanism for EHRs to retrieve a complex set of clinical research instructions (or a protocol) from an formally expressed research protocol to execute within the EHR.

3. Scope
RPE works in the space between the EHR and the clinical research system (EDC). Three actors participate in automating workflow:
Protocol Definition Manager
Protocol State Manager
Protocol Executor

4. Key Technical Properties
RPE is an early adoption of the workflow automation standard Business Process Execution Language (BPEL) applied to formal protocol representation and execution in an EHR.
Web Services will be used to transport the data
XML standard structures will be used to package the messages