2. BioMediTech Over 250 scientists in world-class basic and translational research Tissue engineering and stem cell technology Biomaterials Sensor and actuator technologies Measurement and imaging technologies Biotechnology Immunology Cancer and mitochondrial research Systems biology Bioinformatics Computational methods in biomedicine Joint institute of University of Tampere & Tampere University of Technology

3. Kauppi University Campus Orig. http://www.pshp.fi/

4. BioMediTech aims for excellence in -education -basic research -translational research houses state-of-the-art laboratories and 200m 2 GMP- level clean rooms EMEA approved GMP stem cell production unit Aiming for Excellence

5. Example of Research Excellence BioMediTech: world leader in stem cell based reconstructions of cranial bones 22 cases operated combination of biomaterials and stem cells differentiated from subcutaneous fat 2 months post op 28 months post op Nearly 20 M project funding for Human Spare parts program (2011-2015) Development of tissue engineering products and supporting technologies Tekes, Academy of Finland, Council of Tampere Region, EU

6. Tissue engineering at Regea Adult stem cells Embryonic stem cells iPSCs Production in GMP and own xenofree media Cardiac, neural, opthalmological, soft and hard tissue applications

7. Adipose stem cells Stem cells can be isolated from the patients own adipose tissue, differentiated in vitro and transplanted back into the host tissue rejections are avoided S.Miettinen

8. Adipose stem cells Differentiate to.... Adipocytes Osteocytes Chondrocytes Tendocytes and also to Neural cells? (Cardio)myocytes? Hepatocytes? Epi/Endothelial cells? Adapted from www.nationalacademies.org/stemcells, Wellen and Hotamisligil 2003, Hotamisligil 2006 by Bettina Lindroos Adipose stem cells

9. Neurosurgery Tampere University Hospital: Prof. Juha Öhman

10. Adipose stem cells and biomaterial hASC, β- TCP