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Published byQuentin Crevier Modified over 6 years ago
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Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation
Hani Harb, MSc, Diana Raedler, PhD, Nikolaus Ballenberger, PhD, Andreas Böck, PhD, Dörthe A. Kesper, PhD, Harald Renz, MD, Bianca Schaub, MD Journal of Allergy and Clinical Immunology Volume 136, Issue 1, Pages (July 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig 1 Histone acetylation at both H3 and H4 histones. A, Histone acetylation for TH1 genes IFNG and TBX21 showing no difference between HC children and children with AA. B, Histone acetylation for TH2 genes IL4, IL5, and IL13 showing a significant increase in histone acetylation at histone H3 at the IL13 locus in parallel with a trend for increased H4 acetylation in children with AA compared with HC children. C, Histone acetylation for FOXP3 showing a trend for increased H3 acetylation in children with AA compared with HC children; data presented as mean ± SE; n(HCs) = 18, n(AA) = 14; P value from Kruskal-Wallis test (IL13 H3/H4) or Tobit regression analysis (FOXP3 H3). *P < .05. Journal of Allergy and Clinical Immunology , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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