1. Crohn's disease and cheilitis granulomatosa: Role of silicone fillers
Helena Álvarez-Garrido, MD, Laura Pericet-Fernández, MD, Gerardo Martínez-García, MD, Jose Antonio Tejerina-García, MD, Ignacio Peral-Martínez, MD, Alberto Miranda-Romero, MD 
Journal of the American Academy of Dermatology 
Volume 65, Issue 1, Pages (July 2011)
DOI: /j.jaad
Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

2. Fig 1
Cheilitis granulomatosa. A, A firm, nonpainful and well-demarcated 1.5-cm nodule was palpated on the right side of the upper lip. B, “Swiss cheese pattern” characteristic of liquid silicone granuloma. C, Use of a scanning electron microscope equipped with an energy dispersive spectrometer showed oxygen and carbon that confirmed the presence of organic material, gold, which is usually used to make electrically conductive material, and silica, which indicates the presence of silicon. The finding of sodium in the chemical analysis may be related to the presence of saliva in the biopsy specimen. D, Metallographic reflection microscopy verified the location of the foreign body inside the vacuolated macrophages.
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad )
Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

3. Fig 2
Metastatic Crohn's disease. A, Tender, indurated, erythematous nodules with violaceous margins and peripheral desquamation measuring between 2 and 4 cm located on lateral and posterior legs bilaterally. B, Perivascular inflammatory infiltrate in the reticular dermis organized into noncaseating epithelioid granulomas, composed of numerous epithelioid cells, lymphocytes, Langerhans giant cells, and eosinophils. The infiltrate extended into the subcutaneous tissue.
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad )
Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions