Presentation is loading. Please wait.

Presentation is loading. Please wait.

Tracheal Replacement With a Silicone-Stented, Fresh Aortic Allograft in Sheep  Hisashi Tsukada, MD, PhD, Armin Ernst, MD, Sidhu Gangadharan, MD, Simon.

Published byΆκανθα Ζηναις Πολίτης Modified over 6 years ago

Similar presentations

Presentation on theme: "Tracheal Replacement With a Silicone-Stented, Fresh Aortic Allograft in Sheep  Hisashi Tsukada, MD, PhD, Armin Ernst, MD, Sidhu Gangadharan, MD, Simon."— Presentation transcript:

1 Tracheal Replacement With a Silicone-Stented, Fresh Aortic Allograft in Sheep 
Hisashi Tsukada, MD, PhD, Armin Ernst, MD, Sidhu Gangadharan, MD, Simon Ashiku, MD, Robert Garland, RTT, Diana Litmanovich, MD, Malcolm DeCamp, MD  The Annals of Thoracic Surgery  Volume 89, Issue 1, Pages (January 2010) DOI: /j.athoracsur Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Sheep #3 at 3 months. (A) Computed tomography revealed distal airway migration of a silicone stent. (B) The migrated stent with graft was removed by rigid bronchoscope. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Parallel bronchoscopic (left) and computed tomography (right) images in sheep 10. (A) Yellowish-white aortic graft was seen through the stent and computed tomography revealed thick reactive tissue surrounding the stent at 2 weeks after surgery. (B) Partial aortic graft defect was seen and hypervascular reaction tissue was observed at 2 months. (C) Aortic graft invisible and grafted area was replaced with connective tissue at 1 year. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Bronchoscopic findings of sheep 8 at 1 month after surgery. (A) Yellowish-white specimen was observed at the end of the silicone stent. (B) Same specimen confirmed as necrotic aorta with calcification (hematoxylin and eosin; original magnification, ×100). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Computed tomography traced metal marker in sheep 10 at 2 weeks (A) and 1 year (B). Distal native trachea shifted up toward the proximal; no neocartilage ring was detected at grafted area. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Gross morphology of a harvested specimen in sheep 7 at 6 months. (A) Suture materials were confirmed at the both ends of native trachea. (B) Grafted area length was 1.5 cm in diameter. (C) No evidence of neocartilage formation between proximal and distal native tracheal cartilage ring. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Necrotic aortic graft without any incorporation into surrounding tissue at 12 days after tracheal replacement (hematoxylin and eosin; original magnification, ×50; from sheep 1). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

8 Fig 7 Graft harvested from sheep 10 at 1 year after tracheal replacement (original magnification, ×6). (A) Mucociliary epithelialization was observed at the grafted area without signs of neocartilage formation (hematoxylin and eosin staining). (B) Safranin-O stains were strongly positive only at the native tracheal cartilage. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

9 Fig 8 Mucociliary epithelium was confirmed on the fibrous connective tissue at grafted area on 1 year after the surgery (hematoxylin and eosin; original magnification, ×630; from sheep 2). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Download ppt "Tracheal Replacement With a Silicone-Stented, Fresh Aortic Allograft in Sheep  Hisashi Tsukada, MD, PhD, Armin Ernst, MD, Sidhu Gangadharan, MD, Simon."

Similar presentations

Recurrent Laryngeal Nerve Paralysis by Compression From a Tracheal Diverticulum  Laurens J. Ceulemans, MD, Philip Lerut, MD, Stefan De Moor, MD, Rob Schildermans,

Recurrent Laryngeal Nerve Paralysis by Compression From a Tracheal Diverticulum  Laurens J. Ceulemans, MD, Philip Lerut, MD, Stefan De Moor, MD, Rob Schildermans,
BRCA1 Gene Mutation in Thymic Malignant Melanoma

BRCA1 Gene Mutation in Thymic Malignant Melanoma
Jennifer L. Wilson, MD, Erik Folch, MD, Michael S

Jennifer L. Wilson, MD, Erik Folch, MD, Michael S
Late Complications of Gelatin-Resorcin-Formalin Glue in the Repair of Acute Type A Aortic Dissection  Hiroki Hata, MD, PhD, Hiroshi Takano, MD, PhD, Goro.

Late Complications of Gelatin-Resorcin-Formalin Glue in the Repair of Acute Type A Aortic Dissection  Hiroki Hata, MD, PhD, Hiroshi Takano, MD, PhD, Goro.
Successful Treatment of Infected Ascending Aortic Prosthesis by Omental Wrapping Without Graft Removal  Gordan Samoukovic, MD, Pierre-Luc Bernier, MD,

Successful Treatment of Infected Ascending Aortic Prosthesis by Omental Wrapping Without Graft Removal  Gordan Samoukovic, MD, Pierre-Luc Bernier, MD,
Tracheal Regeneration Following Tracheal Replacement With an Allogenic Aorta  Emmanuel Martinod, MD, PhD, Agathe Seguin, MD, Muriel Holder-Espinasse, MD,

Tracheal Regeneration Following Tracheal Replacement With an Allogenic Aorta  Emmanuel Martinod, MD, PhD, Agathe Seguin, MD, Muriel Holder-Espinasse, MD,
Fascia Temporalis Free Flap for Cricotracheal Reconstruction: A Novel Approach  Bertrand Baujat, MD, PhD, Samuel Struk, MD, Maria Lesnik, MD, MS, Olivier.

Fascia Temporalis Free Flap for Cricotracheal Reconstruction: A Novel Approach  Bertrand Baujat, MD, PhD, Samuel Struk, MD, Maria Lesnik, MD, MS, Olivier.
Serkan Burç Deşer, MD, Mustafa Kemal Demirağ, MD 

Serkan Burç Deşer, MD, Mustafa Kemal Demirağ, MD 
Randall R. De Martino, MD, MS, Jill Johnstone, MD, Elizabeth A

Randall R. De Martino, MD, MS, Jill Johnstone, MD, Elizabeth A
Giant Aortic Thrombus in the Ascending Aorta and Perforation of Bowel Associated With Cocaine Use  Shi Sum Poon, MBChB, Omar Nawaytou, MD, Alfred Hing,

Giant Aortic Thrombus in the Ascending Aorta and Perforation of Bowel Associated With Cocaine Use  Shi Sum Poon, MBChB, Omar Nawaytou, MD, Alfred Hing,
Morphologic Assessment of Extracellular Matrix Scaffolds for Patch Tracheoplasty in a Canine Model  Thomas W. Gilbert, PhD, Sebastien Gilbert, MD, Matthew.

Morphologic Assessment of Extracellular Matrix Scaffolds for Patch Tracheoplasty in a Canine Model  Thomas W. Gilbert, PhD, Sebastien Gilbert, MD, Matthew.
Circumferential Three-Dimensional–Printed Tracheal Grafts: Research Model Feasibility and Early Results  Faiz Y. Bhora, MD, Erik E. Lewis, MD, Sadiq S.

Circumferential Three-Dimensional–Printed Tracheal Grafts: Research Model Feasibility and Early Results  Faiz Y. Bhora, MD, Erik E. Lewis, MD, Sadiq S.
Short-Course Rapamycin Treatment Preserves Airway Epithelium and Protects Against Bronchiolitis Obliterans  Jacob R. Gillen, MD, Yunge Zhao, MD, PhD,

Short-Course Rapamycin Treatment Preserves Airway Epithelium and Protects Against Bronchiolitis Obliterans  Jacob R. Gillen, MD, Yunge Zhao, MD, PhD,
Septimiu D. Murgu, MD, Henri G. Colt, MD 

Septimiu D. Murgu, MD, Henri G. Colt, MD 
Three-Dimensional-Printed Bioengineered Tracheal Grafts: Preclinical Results and Potential for Human Use  Sadiq S. Rehmani, MD, Adnan M. Al-Ayoubi, MD,

Three-Dimensional-Printed Bioengineered Tracheal Grafts: Preclinical Results and Potential for Human Use  Sadiq S. Rehmani, MD, Adnan M. Al-Ayoubi, MD,
Thoracic Pseudoaneurysm Caused By Malignant Lymphoma

Thoracic Pseudoaneurysm Caused By Malignant Lymphoma
Giant Costal Osteochondroma in a Man With Multiple Exostoses

Giant Costal Osteochondroma in a Man With Multiple Exostoses
Ergun Demirsoy, MD, Kamil Umut Sarkislali, MD 

Ergun Demirsoy, MD, Kamil Umut Sarkislali, MD 
Radial Artery Angiographic String Sign: Clinical Consequences and the Role of Pharmacologic Therapy  Senri Miwa, MD, PhD, Nimesh Desai, MD, Tadaaki Koyama,

Radial Artery Angiographic String Sign: Clinical Consequences and the Role of Pharmacologic Therapy  Senri Miwa, MD, PhD, Nimesh Desai, MD, Tadaaki Koyama,
Tissue Reaction to Porcine Intestinal Submucosa (CorMatrix) Implants in Pediatric Cardiac Patients: A Single-Center Experience  Frances Rosario-Quinones,

Tissue Reaction to Porcine Intestinal Submucosa (CorMatrix) Implants in Pediatric Cardiac Patients: A Single-Center Experience  Frances Rosario-Quinones,

Similar presentations

Ads by Google