1. Sitosterolemia: platelets on high-sterol diet
by Hervé Falet
Blood
Volume 122(15):
October 10, 2013
©2013 by American Society of Hematology

2. Impaired ABCG5/ABCG8 heterodimer function in Abcg5−/− or Abcg8−/− hepatocytes and enterocytes leads to increased plasma sterol levels.
Impaired ABCG5/ABCG8 heterodimer function in Abcg5−/− or Abcg8−/− hepatocytes and enterocytes leads to increased plasma sterol levels. Sterols accumulate in the platelet membrane, resulting in calpain activation, reduced αIIbβ3 surface expression, loss of the GPIbα-FlnA linkage, microparticle formation, and poor hemostatic functions.
Hervé Falet Blood 2013;122:
©2013 by American Society of Hematology