1. LC unit recordings in unrestrained narcoleptic dogsAQ CG IC
2 msec
25 µV BC R7 5M BC
5MET R3
Wu, Gulyani et al. 1999
Unit
Hipp
EMG
EOG
EEG
nonREM
REM
5 sec QW
LC unit recordings in unrestrained narcoleptic dogs

2. A B C D LC unit recordings in unrestrained narcoleptic dogs EOG EMG
Hipp
Units
Cataplexy onset
4 sec
Cataplexy offset
Time (sec) 1
spikes/bin
Mean 30
Amplitude (mV) 20
-20 A B C D
Wu, Gulyani et al. 1999
LC unit recordings in unrestrained narcoleptic dogs

3. Locus coeruleus (noradrenergic) Dorsal raphe (serotonergic)
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
Locus coeruleus
(noradrenergic)
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
1.6
Dorsal raphe
(serotonergic)
Discharge rate (Hz) 7
Tuberomammillary
(histaminergic) 6 5 4 3 2 1
John, Wu, Boehmer, Siegel, Neuron 2004 AW QW
SWS
REM
CAT

4. Locus coeruleus (noradrenergic) Dorsal raphe (serotonergic)
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
Locus coeruleus
(noradrenergic)
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
1.6
Dorsal raphe
(serotonergic)
Discharge rate (Hz) 7
Tuberomammillary
(histaminergic) 6 5 4 3 2 1
John, Wu, Boehmer, Siegel, Neuron 2004 AW QW
SWS
REM
CAT

5. John, Wu, Boehmer, Siegel, Neuron 2004