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Cardiomyocyte transplantation does not reverse cardiac remodeling in rats with chronic myocardial infarction  Yutaka Sakakibara, MD, Keiichi Tambara,

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Presentation on theme: "Cardiomyocyte transplantation does not reverse cardiac remodeling in rats with chronic myocardial infarction  Yutaka Sakakibara, MD, Keiichi Tambara,"— Presentation transcript:

1 Cardiomyocyte transplantation does not reverse cardiac remodeling in rats with chronic myocardial infarction  Yutaka Sakakibara, MD, Keiichi Tambara, MD, Fanglin Lu, MD, Takeshi Nishina, MD, Noritoshi Nagaya, MD, Kazunobu Nishimura, MD, PhD, Masashi Komeda, MD, PhD  The Annals of Thoracic Surgery  Volume 74, Issue 1, Pages (July 2002) DOI: /S (02)

2 Fig 1 Experimental protocol. (Blood sample = measurement of atrial natriuretic peptide in plasma;Cath. = measurement of left ventricular pressure and volume using a micromanometer-tipped catheter; Echo = echocardiography; LAD = left anterior descending artery;Treatment = culture medium injection or fetal cardiomyocyte transplantation.) The Annals of Thoracic Surgery  , 25-30DOI: ( /S (02) )

3 Fig 2 (A through D) Results of cardiac function by echocardiography between fetal cardiomyocyte transplantation (TX) and control groups before and after treatment. There were no significant differences in each group before versus after treatment. The TX group had smaller left ventricular (LV) end-systolic dimension and higher fractional shortening and fractional area change. (E) Scar thickness. The ventricular wall in infarct area was thicker in the TX group. (F) Plasma levels of atrial natriuretic peptide (ANP; pg/mL) between the two groups before and after treatment. No significant differences were shown before versus after treatment in each group, or between the groups in each time point. (NS = not significant.) The Annals of Thoracic Surgery  , 25-30DOI: ( /S (02) )

4 Fig 3 Photomicrographs of transplanted fetal cardiomyocytes in the periinfarct area of the left venticular free wall in the transplantation group 4 weeks after the second operation (magnification: A, ×40; B, ×200), and transplanted cardiomyocytes labeled by PKH26 red fluorescent dye (magnification: C, ×40; D, ×100). Panel B is enlargement of inset in A; panel D is enlargement of inset in C. The Annals of Thoracic Surgery  , 25-30DOI: ( /S (02) )

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