1. Understanding Statin Metabolism

3. Patients Most at Risk For Statin-Drug Interactions

4. Common Drug Classes That May Interact With Statins

5. Basics of Statin Metabolism

6. What Happens to Statins in the Body?*

7. Hydrophilic vs Lipophilic Statins

8. "First Pass" Metabolism

9. "First Pass" Metabolism (cont)

10. "First Pass" Metabolism (cont)

11. Molecular Structure of Statins

12. Statin Drug Properties Overview

13. Selected Drug Interactions That Increase Statin Levels

14. Statin-Associated Myopathy Risk Factors

15. Statin Dosing Considerations

16. Simvastatin Label Change Due to Drug Interactions

17. Gender Differences in Response to Statins

18. Racial Differences in Response to Statins

19. INTREPID Trial Statin Therapy in HIV Patients

20. INTREPID Trial Results

21. REPRIEVE Trial

22. REPRIEVE Trial Hypotheses

23. Why Pitavastatin?

24. Statin Dose Adjustment Based on Renal Function

25. Intensity of Statin Therapy

26. Statin-Associated Muscle Symptoms vs Statin Intolerance

27. Management of Statin-Related AEs

28. Clinical Management of the Patient

29. Conclusion

30. Abbreviations

31. Abbreviations (cont)

32. Abbreviations (cont)