1. Improper localization of the NR2B subunit in synaptic and perisynaptic regions in YF/YF mice.
Improper localization of the NR2B subunit in synaptic and perisynaptic regions in YF/YF mice. (A) Postembedding immunogold staining of NR2B subunits at asymmetrical axo‐spinous synapses in the LA of WT/WT (WT/WT1 in B) and YF/YF (YF/YF1 in B) mice. NT, nerve terminal; Sp, spine. The calibration bar, 50 nm. (B–D) Tangential distribution of the NR2B subunit (WT/WT, 88 synapses; YF/YF, 102 synapses). (B) Histograms for the tangential distribution of NR2B subunits at synapses of WT/WT and YF/YF mice. Arrows indicate a boundary of the PSD. (C) Ratio of the number of immunogold particles for the NR2B subunit in the central region to that in the peripheral region. *P<0.01, Student's t‐test. (D) The number of immunogold particles for the NR2B subunit in the perisynaptic regions. Results are expressed as percent of the total number of immunogold particles at synapses. *P<0.03, Student's t‐test. (E) Histograms for the perpendicular distribution of NR2B subunits at synapses of WT/WT (66 synapses) and YF/YF mice (72 synapses). (F) The number of immunogold particles for the NR2B subunit per profile of synapses in the LA of the WT/WT (447 synapses) and YF/YF (451 synapses) mice. P>0.7, Student's t‐test.
Takanobu Nakazawa et al. EMBO J. 2006;25:
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