1. Increase in prescribing of systemic tetracyclines and isotretinoin for treatment of acne vulgaris in Norwegian adolescents from 2005 to 2014
Ingvild Odsbu1, Randi Selmer2, Cecilia Stålsby Lundborg1 and Hege Salvesen Blix2
1Department of Public Health Sciences, Karolinska Institutet, Stockholm
2Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Oslo

2. Aim
To investigate the prescribing of systemic drug therapy for the treatment of severe acne vulgaris in adolescents over a 10 year period

3. Materials and methods The Norwegian prescription database
Period 2005 – 2014
Individuals aged years
Tetracyclines (doxycycline, lymecycline, oxytetracycline and tetracycline) and isotretinoin

4. Treatment of severe acne vulgaris
Disturbs the normal gut microbiota
Contributes to antibiotic resistance
Gives side effects
Systemic tetracyclines
Isotretinoin
Teratogenic

5. Increase in one-year prevalence

6. Increase in incidence rate

7. Conclusions
Increased prescribing rates observed in the period
Tetracyclines most commonly prescribed
Isotretinoin increasingly prescribed
Tetracyclines: greater increase in prevalence and incidence of use in women compared to men