1. ADAPTABLE Aspirin Trial Update
GPC Global Call
April 20, 2017

2. GPC Cumulative Approach by Week

3. GPC Active Site Report April 20, 2017
Approached
Visit Portal
Enrolled
Iowa
5274
228
111
KUMC
3916
269
114
MCW
2741
100 38
Marshfield
1927
104 51
UTSW
254 23 15
Missouri
617 28 10
Nebraska
102 7 3
Total
14831
759
342
% of Approached
5.12%
2.31%
*GPC monthly average since first site’s activation
~4 patients/site/mo.
~25 patients/mo. across all sites

4. Enrollment Concerns CDRN Expectation: enroll 3,658 over next year
At 2.5% avg. enrollment rate, GPC needs to approach 160,000 patients to meet goal
145,000 additional patients over next year
Iowa has an estimate of 14,000 with new phenotype
Seen in last 2 years in any clinic/department at UIHC
If # applied to all participating sites: ~130,500 potentially eligible
@ 2.5% only 3,263 enrolled if all approached

5. Let’s “turn the curve” Higher enrollment rates and approach numbers
Engage with in-clinic and telephone follow-up
Vanderbilt example: off-set costs of research assistants with per capita enrollment payments
Best practice: study invite from PCP or cardiologist
More difficult to operationalize invitations en masse
“Go big or go home” approaches: mass /EHR message/letters
If possible to combine mass mailings with invitation addressed by PCP or cardiologist, do it
Electronic methods

6. Self-Reported Invitation Mode, Identified Participants Visiting Portal University of Iowa
Everyone in our cohort received a letter ~5,300 people
Less than half of them received /EHR follow-up ~2,000
Yet electronic modes are reported slightly more often as an invitation mode by patients in the portal when they go to visit than letters
They save money, and are driving people to the patient portal just as often as letters
March 28, 2017

7. Self-Reported Invitation Mode, Randomized Participants University of Iowa
Same idea but broken down to randomized participants
Again, electronic methods are effective at getting individuals to enroll, but slightly less than letters
In clinic biased a bit since our study nurse usually confirms that a patient wants to enroll with her in clinic before entering a study id into the portal
March 28, 2017

8. Randomized Participants by # Contact Attempts University of Iowa
Receiving boost in enrollment by contacting individuals multiple times
Multi-touch ROI
March 28, 2017

9. Other Updates Phase I Review complete (March 1, 2017)
Thanks to all who helped
Under Continuing Review, GPC lead IRB at Iowa
Indiana final site to onboard following CR approval
UTHSCSA active as of March 1, 2017
Finalizing CP v.2 with chart review
Goal for first invite release: June 1, 2017

10. “First rodeo”