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limit of light microscope

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Presentation on theme: "limit of light microscope"— Presentation transcript:

1 limit of light microscope
cm microns Angstroms 1 10, ,000,000 aorta 0.1 1, ,000,000 blood vessels ,000,000 capillaries ,000 blood cells ,000 bacteria limit of light microscope ,000 viruses protein molecules amino acids atoms

2 limit of light microscope
cm microns Angstroms 1 10, ,000,000 aorta 0.1 1, ,000,000 blood vessels ,000,000 capillaries ,000 blood cells ,000 bacteria limit of light microscope ,000 viruses protein molecules amino acids atoms

3 limit of light microscope
cm microns Angstroms 1 10, ,000,000 aorta 0.1 1, ,000,000 blood vessels ,000,000 capillaries ,000 blood cells ,000 bacteria limit of light microscope ,000 viruses protein molecules amino acids atoms

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9 Aerial view of the Advanced Photon Source

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14 Structure-based drug design
H O O H A c N H H O O O H O H O H H N N H 2 H N O H A c N H H O O O H Varghese et al, 1992 O H Zanamivir O H von Itzstein et al, 1993

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16 Pyrexia in influenza A virus infected ferrets
41 40 39 38 37 36 control TEMP - Degrees C 0.05 mg/kg 4-guanidino-Neu5Ac2en 41 40 39 38 37 36 Pre-infection mean 2 Std dev TEMP - Degrees C DAYS - Post infection Von Itzstein et al (1993) Nature

17 Log Mean Viral Titer Infected Subjects
log10TCID50/ml Study Day

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