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A Molecular Code for Imprinting Drug-Cue Associations

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Presentation on theme: "A Molecular Code for Imprinting Drug-Cue Associations"— Presentation transcript:

1 A Molecular Code for Imprinting Drug-Cue Associations
Adrian M. Gomez, Michael R. Bruchas  Neuron  Volume 96, Issue 1, Pages 3-5 (September 2017) DOI: /j.neuron Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Experimental Paradigm of HDAC5 Regulation of Cocaine Addiction-Related Behaviors in Nucleus Accumbens GABA Neurons Cocaine-induced phosphorylation mediates HDAC5 export to the cytoplasm and allows (green arrows) for cocaine-mediated gene transcription. Expression of a dephosphorylated form of HDAC5 induces nuclear import to negatively regulate (red bars) Npas4 and related genes implicated in cocaine-context learning. Neuron  , 3-5DOI: ( /j.neuron ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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