1. Behaviorally dependent allele-specific expression.
Behaviorally dependent allele-specific expression. (A) Cartoon representation of allele-specific expression under different contexts. In context 1, the sequence in the transcription factor binding site (TFBS1) is identical in the two alleles, leading to an expected ∼50:50 allelic ratio in the F1 hybrid. In context 2, there is a variant between the species in TFBS2 leading to ASE in the F1 hybrid. (B) Bar plots indicating the distribution of significantly differentially biased genes across building and digging contexts. Significance was calculated using a Fisher’s exact test; ***P < 5 × 10−5. (C) Semantic similarity of GO biological process terms enriched for genes with diffASE. Node size is the log of the size of the category represented. Nodes are colored by the log10 P value of the enrichment. (D) An example of a result from a sign test comparing context-dependent allele-specific expression (signal transduction; Reactome pathway R-HSA ).
Ryan A. York et al. PNAS 2018;115:47:E11081-E11090
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