1. Friedel–Crafts reaction

2. What is the reaction? Formation of C–C bond to aromatic ring Two types
C–C bond forms
Alkylation substitution with R e.g. CH3Cl
Acylation substitution with R–CO e.g. CH3COCl

3. Alkylation Reagents and conditions Alkyl chloride, RCl
Halogen carrier catalyst, e.g. AlCl3
Anhydrous conditions

4. Examples of alkylation
Substitution with CH3Cl
Substitution with C2H5Cl
C–C bond forms

5. Acylation Reagents and conditions Alkyl chloride, RCOCl
Halogen carrier catalyst, e.g. AlCl3
Anhydrous conditions

6. Examples of acylation Substitution with CH3COCl
Substitution with C2H5COCI
C–C bond forms