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High-Dose Infusional Gemcitabine Combined with Busulfan and Melphalan with Autologous Stem-Cell Transplantation in Patients with Refractory Lymphoid.

Published byYuliana Tanuwidjaja Modified over 6 years ago

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Presentation on theme: "High-Dose Infusional Gemcitabine Combined with Busulfan and Melphalan with Autologous Stem-Cell Transplantation in Patients with Refractory Lymphoid."— Presentation transcript:

1 High-Dose Infusional Gemcitabine Combined with Busulfan and Melphalan with Autologous Stem-Cell Transplantation in Patients with Refractory Lymphoid Malignancies  Yago Nieto, Peter Thall, Ben Valdez, Borje Andersson, Uday Popat, Paolo Anderlini, Elizabeth J. Shpall, Roland Bassett, Amin Alousi, Chitra Hosing, Partow Kebriaei, Muzaffar Qazilbash, Erin Frazier, Alison Gulbis, Christina Chancoco, Qaiser Bashir, Stefan Ciurea, Issa Khouri, Simrit Parmar, Nina Shah, Laura Worth, Gabriela Rondon, Richard Champlin, Roy B. Jones  Biology of Blood and Marrow Transplantation  Volume 18, Issue 11, Pages (November 2012) DOI: /j.bbmt Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Cytotoxicity of gemcitabine/busulfan/melphalan (Gem/Bu/Mel) on chemotherapy-resistant J45.01 cells. (A) Cell proliferation. (B) Immunoblot staining. Bu or B, busulfan; Mel or M, melphalan; Gem or G, gemcitabine, BM, bone marrow; PARP1, poly ADP-ribose polymerase; BG, busulfan/gemcitabine; MG, melphalan/gemcitabine; BMG, busulfan/melphalan/gemcitabine; Rel, relative. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Event-free survival (EFS) and overall survival (OS) of the main histologic subsets. (A) Hodgkin lymphoma. (B) B-large cell lymphoma. Post-HDC, high-dose chemotherapy. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

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