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Patient Presentation. Dyslipidemia Management Beyond Statins: Will PCSK9 Inhibition Trigger a Revolution?

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Presentation on theme: "Patient Presentation. Dyslipidemia Management Beyond Statins: Will PCSK9 Inhibition Trigger a Revolution?"— Presentation transcript:

1 Dyslipidemia Management Beyond Statins: Will PCSK9 Inhibition Trigger a Revolution?

2 Patient Presentation

3 On Exam

4 Patient Follow-Up 8 Weeks

5 Case Questions

6 Estimated Frequency of Individuals With Familial Hypercholesterolemia

7 Problems in Identifying FH Patients

8 Statin Myopathy is a Common Challenge in Lipid Management

9 Statins and New-Onset Type 2 Diabetes Facts and Clinical Implications

10 Case Questions

11 Therapy for Statin Intolerance

12 ODYSSEY FH I + II Alirocumab Significantly Reduced LDL-C From Baseline to Week 24 vs Placebo

13 Safety Analysis (Pooled Data From FH I and FH II)

14 ODYSSEY Combo Alirocumab Significantly Reduced LDL-C From Baseline to Week 25 vs Ezetimibe

15 ODYSSEY LONG TERM Alirocumab Maintained Consistent LDL-C Reduction Over 52 Weeks

16 Adverse Events of Special Interest

17 Post-hoc Adjudicated Cardiovascular Events*

18 Abbreviations

19 Abbreviations (cont)

20 Abbreviations (cont)

21 References

22 References (cont)

23 References (cont)

24 References (cont)

25 References (cont)


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