1. Anergic B Cells Caught in the Act
Fritz Melchers 
Immunity 
Volume 25, Issue 6, Pages (December 2006)
DOI: /j.immuni
Copyright © 2006 Elsevier Inc. Terms and Conditions

2. Figure 1 Development of B-Lymphocytes in Bone Marrow and Spleen
The number of cells in the various compartments (each cell represents 1.25 × 106 cells) and their status of κL chain gene rearrangements (purple cells contain secondary, “edited” κL chain gene loci), as well as estimated daily rates of turnover or transit (within purple box) are shown (see Melchers et al., 2000). G, germline configuration; V→J, rearranged. From pre-BII to naive B cells, all cells are resting and are short lived, with half-lives of 2–4 days. Expression of essential markers (+) defining the different developmental stages is shown at the bottom.
Immunity  , DOI: ( /j.immuni )
Copyright © 2006 Elsevier Inc. Terms and Conditions