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Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis

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Presentation on theme: "Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis"— Presentation transcript:

1 Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis
Erin Greenwood, Emma D. Wrenn, Kevin J. Cheung  Developmental Cell  Volume 40, Issue 4, Pages (February 2017) DOI: /j.devcel Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Lineage-Tracing MaSCs in Mammary Branching Morphogenesis
Upon puberty, TEBs proliferate and bifurcate to generate a branched, bilayered epithelial tree. (A) The authors fluorescently labeled cells randomly before puberty. Labeled MaSCs leave behind a trail of fluorescent progeny along the duct (shown in blue in inset). These MaSCs arise from TEBs. (B) MaSC cell fate is positionally biased, such that cells near the border generate daughters that contribute to ductal elongation, while cells near the tip favor self-renewal. (C) Cells mix within the TEB. MaSCs change position from border to tip and randomly segregate into one of two new branches after bifurcation. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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