1. I can calculate determine inheritance through pedigrees.
Objective:
I can calculate determine inheritance through pedigrees.
Agenda:
Early Morning lab
Bell Ringer
Quiz
Notes over Pedigrees
Kahoot
Review

2. PEDIGREES AND GENETIC COUNSELING
Chapter 6
Queen Victoria and Prince Albert of the United Kingdom were cousins who had 9 children. Queen Victoria was a carrier for Hemophilia and passed is on to 4 of her children.

3. _______________________________________
PEDIGREE ANALYSIS
_______________________________________
Chart of genetic connections in a family:
1. _________________________________
-based upon observed pattern in pedigree
2. _________________________________
-controlled breeding experiments not ethical in humans
-extremely long generation time
-few offspring

4. Pedigree Symbols

5. What can pedigree analysis tell us?
1. Mode of inheritance
_______________________
autosomal recessive
X-linked dominant
________________________
______________________
2. ________________________

6. How to determine mode of inheritance
1. Autosomal dominant
-________________________
-affected child from at least 1 parent
-if 1 parent is affected and other is not, about 1/2 of children affected
-_____________________________________________________________________

7. 7

8. 2. Autosomal recessive -____________________________
-< affected than unaffected individuals
-both parents affected, ALL children affected
-______________________________________________________________
-both sexes equally affected (autosomal & not sex-linked)

9. 9

10. 3. X-linked dominant -_______________________________
-________________________________________________________________________
-affected female children from only 1 affected parent (X-linked recessive requires both parents be affected to produce affected daughter)

11. 11

12. 4. X-linked recessive -_____________________________
-________________________________________________________________________
-affected fathers and non-carrier mothers never have affected children
-carrier mothers and normal fathers can have affected sons, but not affected daughters
-about 1/2 of sons from carrier mothers will be affected

13. 13

14. Hemophilia, an X-linked recessive disorder

15. 5. Y-linked traits
_________________________
Passed from father to all sons, no daughters