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Kathie Alexina Wong, Mark Wass, Kay Thomas  European Urology 

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1 The Role of Protein Modelling in Predicting the Disease Severity of Cystinuria 
Kathie Alexina Wong, Mark Wass, Kay Thomas  European Urology  Volume 69, Issue 3, Pages (March 2016) DOI: /j.eururo Copyright © 2015 European Association of Urology Terms and Conditions

2 Fig. 1 Structural analysis of b(0+)AT mutations. (A) A structural model of b(0+)AT was generated and residues involved in amino acid transport were identified (cyan). Mutations (red) were mapped to analyse their potential structural and functional effects. (B) p.Gly105Arg is located at the end of the channel where amino acids are transported. (C) Some mutations (p.Arg171Trp, p.Arg333Trp) are located close to the end of the membrane and could affect membrane stability. European Urology  , DOI: ( /j.eururo ) Copyright © 2015 European Association of Urology Terms and Conditions


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