1. Anti-inhibitor coagulant complex
Drugbank ID : DB13151
Half life : 4-7 hours
Description :
Anti-inhibitor coagulant complex is a freeze-dried sterile human plasma fraction with factor VIII inhibitor bypassing activity to be reconstituted for intravenous administration. Anti-inhibitor coagulant complex contains mainly non-activated factors II, IX, and X and mainly activated factor VII. It is manufactured from large pools of human plasma.

2. Indication :
Controlling bleeding episodes or bleeding during surgery in patients who have hemophilia A or B with inhibitors.
Pharmacodynamics :
Multiple interactions of the components in anti-inhibitor coagulant complex restore the impaired thrombin generation of hemophilia patients with inhibitors. In vitro, anti-inhibitor coagulant complex shortens the activated partial thromboplastin time of plasma containing factor VIII inhibitor.

3. Categories : Blood Coagulation Factors, Antihemophilic Agent
Brands : Feiba Nf
Company : E.R. Squibb & Sons, L.L.C.
Form : Solid
Route of administration : Intravenous

4. Dosage : units/kg per dose (maximum: 100 units/kg [single dose], 200 units/kg/day [total daily dose]). Dosage and duration of treatment depend on the location and extent of bleeding and clinical condition of the patient. Contraindication : Known anaphylactic or severe hypersensitivity to anti-inhibitor coagulant complex or any component of the formulation, including factors of the kinin generating system; disseminated intravascular coagulation (DIC); acute thrombosis or embolism (including myocardial infarction) Side effects : chest pain or discomfort

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