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The Reliable Life Defense
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Each vial contains: Each vial contains: Recombinant human granulocyte colony-stimulating factor (G-CSF) 300 µg in a volume of 1 ml. Recombinant human granulocyte colony-stimulating factor (G-CSF) 300 µg in a volume of 1 ml.
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Filgrastim Filgrastim is a glycoprotein which acts on hematopoietic cells in bone marrow, stimulating their proliferation & differentiation to neutrophils. Filgrastim Filgrastim accelerates improvement of neutrophils count & their functional activation (enhanced phagocytic ability) Filgrastim Filgrastim is a glycoprotein which acts on hematopoietic cells in bone marrow, stimulating their proliferation & differentiation to neutrophils. Filgrastim Filgrastim accelerates improvement of neutrophils count & their functional activation (enhanced phagocytic ability)
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To reduce the incidence, severity & duration of neutropenia associated with chemotherapy (Interferon) Cancer patients receiving myelosuppressive chemotherapy Patients with acute myeloid leukemia receiving induction Chemotherapy Patients with severe chronic neutropenia
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Cancer patients undergoing peripheral Blood Progenitor Cell Collection and Therapy Cancer patients receiving bone marrow transplant Patients with acute myeloid leukemia receiving induction Chemotherapy Patients with severe chronic neutropenia
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Filgrastim dose: 4 to 8 mcg/kg for up to 14 consecutive days following each cycle of chemotherapy Duhrsen U Villeval JL Boyd J et al. Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood 1988;72:2074-2081. Cancer Patients Receiving Myelo- suppressive Chemotherapy
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Dosage & Administration is individualized according to patients clinical course & average neutrophil count Filgrastim Filgrastim should be given once daily by I.V. or S.C. injection (after 24 – 48 hours of administration of chemotherapy or radiotherapy)
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Cancer patients receiving myelosuppressive chemotherapy: Cancer patients receiving myelosuppressive chemotherapy: 5 µg/kg body weight /day as a single daily dose by S.C. injection or I.V. infusion over 15 – 30 minutes
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Patients with severe chronic neutropenia: Patients with severe chronic neutropenia: Initial dose Congenital: 6µg/kg body weight twice daily by S.C. injection Idiopathic: 5µg/kg body weight /day as a single S.C. injection
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Cancer patients receiving bone marrow transplant: Cancer patients receiving bone marrow transplant: 10 µg/kg body weight /day as I.V. infusion for 4 – 24 hours
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Cancer patients undergoing peripheral Blood Progenitor Cell Collection and Therapy: Cancer patients undergoing peripheral Blood Progenitor Cell Collection and Therapy: 10 µg/kg body weight /day either as a bolus or a continuous infusion at least 4 days before the first procedure for 6 – 7 days, on day 5,6,7. Dose modification in case of reaching WBCs count exceeding 100,000 / mm 3
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Filgrastim Filgrastim is kept in refrigerator at 2 – 8 o C Filgrastim Filgrastim can be kept at room temp. for a maximum of 24 hours Filgrastim Filgrastim vial should not be shacked Filgrastim Filgrastim vial should not be reused, the unused portion must be discarded
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1 vial (1 ml) … 350 L E. 1 vial (1 ml) … 350 L E.
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The Reliable Life Defense
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