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“TORCing” Neutrophil Chemotaxis

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Presentation on theme: "“TORCing” Neutrophil Chemotaxis"— Presentation transcript:

1 “TORCing” Neutrophil Chemotaxis
Pascale G. Charest, Richard A. Firtel  Developmental Cell  Volume 19, Issue 6, Pages (December 2010) DOI: /j.devcel Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 TORC2 Controls Neutrophil Polarity and Chemotaxis by Regulating F-Actin Polarity and Myosin II Assembly (A) TORC2 is presumably activated at the front of the cells, in a chemoattractant- and Gi-dependent manner, controlling the polarity of F-actin and locally activating PKC. In turn, PKC promotes the activation of AC9 and cAMP production. (B) Through unknown mechanisms, the chemoattractant-stimulated, TORC2/PKC-dependent cAMP production oscillates and becomes enriched at the posterior of cells, where, most likely through PKA acting on RhoA and/or MLCK, it regulates the inhibition of myosin II assembly. Fpr, Formyl peptide receptor. Figure designed and drawn by Jessica Chang. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2010 Elsevier Inc. Terms and Conditions

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