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Keeping ‘Trk’ of Antidepressant Actions

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Presentation on theme: "Keeping ‘Trk’ of Antidepressant Actions"— Presentation transcript:

1 Keeping ‘Trk’ of Antidepressant Actions
Mounira Banasr, Ronald S. Duman  Neuron  Volume 59, Issue 3, Pages (August 2008) DOI: /j.neuron Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Schematic Diagram Summarizing the Cellular Actions of BDNF-TrkB Signaling in the Neurogenic and Behavioral Responses to Antidepressants The study by Li et al. in this issue of Neuron demonstrates that conditional deletion of TrkB in GFAP-positive or Nestin-positive neural progenitor cells blocks the neurogenic and behavioral actions of antidepressant treatment and exercise. In contrast, deletion of TrkB in mature, Synapsin-positive neurons does not influence these responses. Additional studies will be required to determine if BDNF is released from the neural progenitor cells or from mature neurons. QNP, quiescent neural progenitor; ANP, amplifying neural progenitor. Neuron  , DOI: ( /j.neuron ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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