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Current status of pig lung xenotransplantation
Natalia Kubicki, Christopher Laird, Lars Burdorf, Richard N. Pierson, Agnes M. Azimzadeh International Journal of Surgery Volume 23, Pages (November 2015) DOI: /j.ijsu Copyright © 2015 IJS Publishing Group Limited Terms and Conditions
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Fig. 1 (A) A left porcine lung's main bronchus, pulmonary artery, and pulmonary vein are anastamosed to baboon recipient's analogous structures after native left lung removal. (B,C) A rubber snare is left around the right pulmonary artery. Survival of the animal with the RPA intermittently occluded by a ‘vesi-loop’ snare demonstrates adequacy of graft function to support life (C). After chest closure, flow probes around the aorta and one main pulmonary artery (left illustrated, B) allow long-term telemetric monitoring of the proportion of cardiac output traversing the graft, as a proxy for graft function, and to determine timing of diagnostic procedures or therapeutic interventions. International Journal of Surgery , DOI: ( /j.ijsu ) Copyright © 2015 IJS Publishing Group Limited Terms and Conditions
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Fig. 2 Left: Porcine lung on an ex vivo ventilation-perfusion circuit. Ventilator tubing is connected to an endotracheal tube secured in the left main bronchus or trachea (right side). Blood inflow to the lung from the heated reservoir (37 °C) enters the pulmonary artery. Blood outflow drains from the pulmonary vein into the reservoir, and is recirculated. Right: illustrated schematic showing same set-up. International Journal of Surgery , DOI: ( /j.ijsu ) Copyright © 2015 IJS Publishing Group Limited Terms and Conditions
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