1. Controlled Nanoscale Topography and Chemistry for biomaterial interfaces
Dr. Sivashankar Krishnamoorthy
Enabling platform for nanoscale patterns on surface
COST Action Meeting BIONECA,
October 2017, Bucharest

2. Nano-enabled bio-interfaces
LIST Know-How
Plasmonic sensors
PRL 94, (2005)
LSPR, SERS sensors
Enhance biomolecular Density, Kinetics, Orientation, Conformation
PNAS, 2010, 107, 6264
Adv. Mater. 2008, 20, 2782
Engineered Bio-interfaces
Study/Influence cell-behavior p d h
Aleksei Aksimentiev group page, UIUC
Nanosieves
High surface area biosensors
biosensing.wordpress.com359 
Porous Interfaces
200 nm
Enhanced Surfaces
55-60 nm

3. An interplay of multiple parameters
Convergence of optimal choice at each level
Nanopatterned Bio-Interfaces
Feature
Substrate
Shape
Surface-functionalization
Polystyrene, Metal, Glass
profile, Aspect ratio
Ligands, Charges, NPs
Nanopatterns are basically a spatially correlated distribution of nanoscale features on surface
Biocompatible polymers,
Metal, Glass, Polystyrene
Amine, Carboxy, Epoxy, polymeric, PEG-ylated, Lipid-based..

4. Relevant Existing projects
NPs, Molecules
Functionalized Microcarriers mm
PDMS Substrate
DNA Barcode
Functionalized Glass
Cell-Based Devices