1. Neurobiology of MDD for Social and Physical Stress
MDD Vulnerability (e.g. genetics, cell damage)
Neuroprogression
Vulnerability for further episodes and treatment resistant
MDD
Inflammation
Epigenetic Changes
Neurotropic Changes
HPA Axis Dysregulation
Mitochondrial Dysfunction
O&NS
Damage to cellular components
Induction of apoptosis
Inhibited neuronal growth and word?
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Cognitive and functional decline and Structural Abnormalities