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V617F “JAKs” up myeloproliferative signal

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Presentation on theme: "V617F “JAKs” up myeloproliferative signal"— Presentation transcript:

1 V617F “JAKs” up myeloproliferative signal
by Ayalew Tefferi Blood Volume 106(10): November 15, 2005 ©2005 by American Society of Hematology

2 Phenotypic diversity associated with the JAK2 V617F tyrosine kinase mutation might arise from a combination of the particular myeloid progenitor compartment that is affected and specific secondary mutations that occur during clonal evolution. Phenotypic diversity associated with theJAK2V617F tyrosine kinase mutation might arise from a combination of the particular myeloid progenitor compartment that is affected and specific secondary mutations that occur during clonal evolution. Ayalew Tefferi Blood 2005;106: ©2005 by American Society of Hematology


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