Presentation is loading. Please wait.

Presentation is loading. Please wait.

Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study  Lujain.

Published byHarold McKenzie Modified over 6 years ago

Similar presentations

Presentation on theme: "Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study  Lujain."— Presentation transcript:

1 Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study  Lujain H. Albenali, MD, Simon Danby, PhD, Manar Moustafa, MD, Kirsty Brown, BSc, John Chittock, BSc, Fiona Shackley, MD, Michael J. Cork, FRCP  Journal of Allergy and Clinical Immunology  Volume 138, Issue 6, Pages e4 (December 2016) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Presupplementation analysis. A, Baseline VD level comparison. Children with ADEH (black dots, n = 45) with lower VD levels compared with children with AD (gray squares, n = 45). Levels: 50-75 nmol/L (dotted lines), suboptimal; less than 50 nmol/L, deficient. B, Patients with AD (47) classified into severe AD (n = 13), moderate AD (n = 30), and mild AD (n = 4) showed significantly different VD levels. C, Baseline LL-37 levels stratified according to SCORAD were significantly different. D, VD and LL-37 correlation (P = .01). *P < .05 and **P < .01. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Postsupplementation analysis (n = 47). A, SCORAD reduced 42.3% postsupplementation. B, POEM showed significant reduction (46.6%). C, LL-37 levels increased significantly from 2 ± 0.7 Log10(LL-37 pg/g) to 2.8 ± 0.8 Log10(LL-37 pg/g). D, Lesional LL-37 levels increased from 2.3 ± 0.7 Log10LL-37 pg/g to 3 ± 0.7 Log10(LL-37 pg/g). E, Nonlesional LL-37 levels increased from 2.3 ± 0.6 Log10(LL-37 pg/g) to 2.7 ± 0.8 Log10(LL-37 pg/g). Rx, Treatment. **P < .01 and ***P < .001. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Flowchart of study. Ninety children with AD screened for VD deficiency and classified into AD and ADEH groups on initial consultation. Of these 90, 15 were found to have normal VD levels and 75 had low VD levels. Of the 75 children with AD, 18 were lost to follow-up and 10 were excluded. Therefore, 47 children were included in the practice evaluation study. These 47 children were clinically assessed and supplemented. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 The IgE level did not show a significant change from mean score 7010 ± 2370 nmol/L to 7824 ± 3221 nmol/L (P = .93; unpaired t test). Rx, Treatment. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study  Lujain."

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,
A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,
Defective B-cell memory in patients with Down syndrome Ruud H.J. Verstegen, MD, Gertjan J. Driessen, MD, Sophinus J.W. Bartol, BSc, Carel J.M. van Noesel,

Defective B-cell memory in patients with Down syndrome Ruud H.J. Verstegen, MD, Gertjan J. Driessen, MD, Sophinus J.W. Bartol, BSc, Carel J.M. van Noesel,
Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,
Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease  Merja T. Augustin, MD, Jorma Kokkonen, MD,

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease  Merja T. Augustin, MD, Jorma Kokkonen, MD,
Wet Wrap Therapy in Children with Moderate to Severe Atopic Dermatitis in a Multidisciplinary Treatment Program  Noreen Heer Nicol, PhD, RN, FNP, Mark.

Wet Wrap Therapy in Children with Moderate to Severe Atopic Dermatitis in a Multidisciplinary Treatment Program  Noreen Heer Nicol, PhD, RN, FNP, Mark.
Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease  Merja T. Augustin, MD, Jorma Kokkonen, MD,

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease  Merja T. Augustin, MD, Jorma Kokkonen, MD,
Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Atopic dermatitis: Age and race do matter!

Atopic dermatitis: Age and race do matter!
Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema  Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,

Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema  Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,
Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum  Lianghua Bin, MD, PhD, Michael G. Edwards,

Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum  Lianghua Bin, MD, PhD, Michael G. Edwards,
Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population  Hui.

Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population  Hui.
Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD 

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD 
Patient perspectives on the management of atopic dermatitis

Patient perspectives on the management of atopic dermatitis
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
Skin-homing and systemic T-cell subsets show higher activation in atopic dermatitis versus psoriasis  Tali Czarnowicki, MD, Dana Malajian, BA, Avner Shemer,

Skin-homing and systemic T-cell subsets show higher activation in atopic dermatitis versus psoriasis  Tali Czarnowicki, MD, Dana Malajian, BA, Avner Shemer,
An Infant with Atopic Dermatitis and Itching After Ingestion of Milk

An Infant with Atopic Dermatitis and Itching After Ingestion of Milk
Correction Journal of Allergy and Clinical Immunology

Correction Journal of Allergy and Clinical Immunology
Mothers' anxiety during pregnancy is associated with asthma in their children  Hannah Cookson, MB, ChB, Raquel Granell, PhD, Carol Joinson, PhD, Yoav Ben-Shlomo,

Mothers' anxiety during pregnancy is associated with asthma in their children  Hannah Cookson, MB, ChB, Raquel Granell, PhD, Carol Joinson, PhD, Yoav Ben-Shlomo,

Similar presentations

Ads by Google