1. Beyond Statin Therapy

2. Program Goals

3. Overview of Dyslipidemia Management

4. Patient Case 1

5. Challenges of Using Clinical Trial Data to Assess Statin Intolerance

6. PCSK9 Inhibitors in Statin Intolerance ODYSSEY Alternative

7. Safety of Alirocumab Skeletal Muscle AEs

8. Incidence of Muscle AEs With Statins PRIMO Study

9. GAUSS Evolocumab in Statin Intolerance

10. GAUSS-2

11. GAUSS-3 Study Design 2 Double-Blind Phases

12. GAUSS-3 Phase A Study Drug Discontinuation Events

13. GAUSS-3 Efficacy and Safety for Evolocumab

14. Patient Case 2

15. 2016 ACC Expert Consensus Role of Nonstatin Therapies in LDL-C Lowering

16. 2017 AACE Guidelines for the Management of Dyslipidemia

17. PCSK9 Inhibitor CV Outcomes Trials

18. FOURIER Trial Design

19. FOURIER LDL-C Reduction

20. FOURIER CV Outcomes

21. Improving Access to PCSK9 Inhibitors

22. Abbreviations

23. Abbreviations (cont)