1. Food Chemicals Toxicity
On-line course
Training program on Food Chemical Risk Assessment for developing country food safety regulators and the food Industry
Chapter 2 (a-c)
Food Chemicals Toxicity

2. Chapter 2.1 (a-c): Food chemicals – their toxicity
OBJECTIVES
Understanding the steps taking place from the intake of food chemicals
their absorption, distribution in the body, metabolism
and excretion (ADME)
the observed toxic effects
How to assess the severity of effects in animals and humans.

3. Chapter Content overall
Absorption, distribution, metabolism and excretion of food chemiclas
Toxicokinetics (how quick do processes happen) and toxicodynamics (effects) definition
Examples of chemicals and toxicity targets and endpoints
Threshold vs non-threshold mode of action
Dose-response observations in more detail – animal based assays for data aquisition